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If these worms indeed are heavily mutated and actually came from humans, then that would also imply that such an amount of spice exposure causes total mental degradation. Worms seem to act on instinct, and there is no indication they are actually intelligent.
It's an interesting thought, although I don't think it's very likely they as a species evolved out of humans.
very cool topic points!! @Kafkaesque
"Must be something we haven't seen yet.."__Bishop