So with the company that helped make Punch Out Wii, "Next Level Games Inc." announcing work on a new Video Game title helps give a sequel to Punch Out Wii more credence.
So with that said what characters should and will return in Punch Out Wii U? Well, Little Mac is the main Protagonist of the series so you can bet he will return, but will his Coach Doc Louis come back?
Well at the end of Punch Out Wii!! Little Mac gives up his belt and retires from the W.V.B.A (World.Video.Boxing.Association) for a time, now if they make a Reboot of course Doc will be back, but if they make a direct sequel will Doc be back?
Well, Doc has been Little Mac's coach since the beginning, if they did not bring him back it would'nt make any sense i dont think Mac would train under anyone else besides Doc.
So the Odds atleast in my opinion go in Doc's favor for him to return.
Sources: Nintendo Official Punch Out website!