Based on the popular video game. In the not too distant future, humans have successfully colonized the planet Mars. Here scientists were experimenting on naturally occurring substances and using the colonizing humans as guinea pigs. The experiment went horribly wrong. Now, a group of marines and a scientist named Samantha Grimm are going to find out what happened. They teleport to Mars via a system known as the "Arch". What they find are gruesome monsters hell bent on death and destruction. Samantha's brother John is also one of the marines sent to Mars to help.